The information is entered in a calculator which will place the disease in 1 of 6 risk groups: This can only be calculated if molecular testing has been completed. Molecular International Prognostic Scoring System (IPSS-M) uses the same data as the IPSS-R system and also uses the results of molecular testing. The total IPSS-R score places people with MDS into 5 distinct groups: Low levels of hemoglobin, platelets, and neutrophils Higher percentage of blasts in the bone marrow This system looks at factors such as the percentage of blasts found in the bone marrow, type and extent of chromosomal changes, and levels of hemoglobin found in red blood cells, platelets, and a type of white blood cell called neutrophils.Ĭertain types and higher numbers of chromosomal changes Revised International Prognostic Scoring System (IPSS-R). Be sure to ask your doctor any questions you may have about which system they use and what this means for you. Your doctor may use either system for determining prognosis. The types of treatment a person with MDS receives depends on their prognostic score. Both systems determine a person's risk on a range from "very low" to "very high." These system's help predict a person's risk of developing AML and overall survival. There are two systems in place for determining the prognosis of a person with MDS. Genetic changes from chromosome testing and molecular testing Neutrophil is a type of white blood cell. Low blood counts measured by hemoglobin level in red blood cells, platelet number, and neutrophil level. Each system uses three factors, based on results of different tests (see Diagnosis): However, there are scoring systems that doctors use to help predict a person's risk of developing AML and overall prognosis. Return to top Systems for determining prognosis The ICC system classifies different myeloid neoplasms (blood cancers), including MDS, and acute leukemias. This classification system was developed in collaboration with the Society for Hematopathology and the European Association for Haematopathology. International Consensus Classification (ICC) system. This classification system was updated in 2022 and includes 6 different subtypes divided into two categories. The World Health Organization (WHO) developed a classification system for MDS to standardize the definitions of the different subtypes. Your doctor may use one or more of these systems to understand how you are affected by MDS. There are several different systems of classifying MDS and the prognosis for people with MDS. Return to top Systems for MDS classification Each classification and prognostic system is described in more detail below. It can also help predict a patient's prognosis, which is the chance of recovery. Knowing the classification helps the doctor recommend the best kind of treatment. MDS classifications are a way of describing the disease, its severity, the need for treatment, and how long a person with MDS is expected to live, which is called a prognosis.ĭoctors use diagnostic tests to find out the subtype and classification of MDS, so this may not be complete until all of the tests are finished. This is called MDS subtype and classification. ON THIS PAGE: You will learn about how doctors describe myelodysplastic syndromes (MDS).
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